Molecular biological investigation in Candida albicans isolated from recurrent candidiasis of the tongue

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In this study we enrolled the 20 patients in whomCandidawas detected from among 65 patients with a chief complaint of tongue pain. We treated these 20 subjects with an oral antifungal agent, itraconazole, 100mg/day, for 1 to 4 weeks, and the manifestations were resolved clinically in every case except one. Nevertheless, a recurrence developed in 2 of the 20 patients 15 weeks and 17 weeks, respectively, after the initial episode had been cured. We investigated the drug sensitivity and biochemical properties of theCandida albicansisolated initially and at the time of the recurrence in these two cases, and their biochemical properties with API-C-Auxanogram®. The same evaluation results were obtained with both the stains at the time of the initial infection and the recurrence. Next, we performed a karyotype analysis by pulsed-field gel electrophoresis (PFGE), and deduced that they were the same fungal strain based on the patterns obtained and that the recurrences were attributable to colonization.
日本歯科薬物療法学会の論文