Effect of calcium channel blockers on proliferation of human gingival fibroblast (Gin-1).

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Human gingival fibroblast cells were used to clarify the effects of proliferation of a fibroblast cell and DNA synthesis by using calcium channel blocker, nifedipine (NIF), aranidipine (ARA), and nicarudipine (NIC) .<BR>1. Cell proliferation increased significantly, as compared with the control, at the concentrations of 1/10, 1, 10, and 100Cmax in the NIF and ARA-added groups. No increase was seen in the NIC-added group.<BR>2. On comparison between the medicines in cell proliferation, the NIF and ARA-added groups showed a significant increase in the number of cells, as compared with the NIC-added group, at the concentrations of 1/10, 1, and 10Cmax.<BR>3. DNA synthesis was set at the concentrations of 1/10 and 1 Cmax in the NIF-added group, and also in the ARA-added group it was set at the concentrations of 1/10, 1, and 10Cmax. Both groups increased significantly as compared with the control. In the NIC-added group, however, it was not observed at the concentrations.<BR>4. The comparison between the medicines in DNA synthesis, the ARA-added group increased significantly, as compared with the NIF and NIC-added groups, at the concentrations of 1 and 10Cmax.
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