Effects of chronic administration of Cevimeline hydrochloride on salivary secretion in Balb/cA mice.

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The effects of repetitive administration of Cevimeline (SNI-2011), a novel muscarinic receptor agonist, (±) -cis-2-methylspilo [1, 3-oxathiolane-5, 3'-quinuclidine] hydrochlo-ride hemihydrate, on salivary secretion were studied in Balb/cA mice. Saliva flow, protein secretion and amylase activity were measured. Saliva was collected from the oral cavity at intervals of 5 min over 30 min after intraperitoneal injection of 10mg /kg of Cevimeline. The effects of 7 days of Cevimeline administration were compared with the effects of single injection.<BR>Seven-day administration of Cevimeline tended to increase saliva flow over 30-min saliva collection compared with single injection. The rate of saliva release increased significantly in the first 10-min period. Protein concentration in the secreted saliva showed no significant change. The total amylase secretion over 30 min tended to increase.<BR>The results of the present study showed the effects of chronic administration of Cevimeline in salivary function, and suggested that Cevimeline administration twice a day does not evoke tolerance in the salivary gland receptor.
日本歯科薬物療法学会の論文