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A multi-center double-blind study in comparison with aspirin was conducted to evaluate the effectiveness, safety and usefulness of Suprofen (TO-177), a new non-steroidal analgesic/anti inflammatory agent, in tooth extraction of mandibular impacted wisdom tooth. Patients were treated with Suprofen (SP) 100mg three times a day or aspirin (AP) 500mg three times a day. The results were obtained as follows. 1) Total treated cases were 272 (SP: 133 cases, AP: 139 cases) . 4 cases were excluded. 2) According to the clinical efficacy, the ratio of"good or better"was 74.4% with SP group and 61.2% with AP group. There was a significant difference between two groups (p<0.001) . 3) Side effects were reported 3 cases (2.3%) SP group and 10 cases (5.1%) AP group. 4) In the general utility rating, the ratio of"useful or better"was 72.7% with SP group and 56.7% with AP group. There was a significant difference between two groups (p<0.001) . The results indicate that Suprofen is a safe and useful anti inflammatory analgesic agent.
日本歯科薬物療法学会の論文