Anti-cariogenic effects of extracts from eucalyptus leaves on gnotobiotic BALB/cA mice.
スポンサーリンク
概要
- 論文の詳細を見る
Extract of <I>Eucalyptus globulus</I> showed antibacterial activity against several oral bacteria such as <I>Streptococcus mutans</I>, <I>Streptococcus sobrinus</I> and <I>Streptococcus sanguis</I>. It also showed inhibitory effect on glycosyltransferase (GTase of mutans streptococci) <I>in vitro</I>.<BR>In this study, anti-caries activity of extract of <I>E. globulus</I> on <I>S. mutans</I>-infected gnotobiotic BALB/cA mouse model was investigated.<BR>Germ-free BALB/cA mice (5 weeks old) were divided into 1 control group and 3 experimental groups. The control group were fed Diet 2000 (D#2000) containing 30% sucrose and experimental groups were fed D#2000 containing extract of <I>E. globulus</I> at levels of 0.5%, 0.1% and 0.05%. All groups were inoculated with <I>S. mutans</I> ATCC 25175.<BR>The number of <I>S. mutans</I> on the teeth of the experimental groups 0.5% and 0.1% were significantly lower than that of the control group (p<0.01) . That of the 0.5% group was also significantly lower than that of 0.05% group (p<0.05) .<BR>The number of <I>S. mutans</I> in the cecum contents of the experimental groups 0.5% (p<0.01) and 0.1% (p<0.05) were significantly lower than that of the control group. That of the 0.5% group was also significantly lower than those of the 0.1% (p<0.05) and 0.05% groups (p<0.01) .<BR>Caries developed in all mice, however, the mean caries scores of the experimental groups 0.5% and 0.1% were significantly lower than that of the control group (p<0.01) . Further, the mean caries score of the 0.5% group was significantly lower than those of the 0.1% and 0.05% groups (p<0.01) .<BR>The results suggested that extract of <I>E. globulus</I> showed anti-caries activity in gnotobiotic BALB/cA mouse model. This anti-caries activity of extract of <I>E. grobulus</I> might be due to bacteriostatic action of S. mutans, and extract of <I>E. grobulus</I> has an inhibitory effect on GTase of <I>S. mutans</I>.
- 日本歯科薬物療法学会の論文
日本歯科薬物療法学会 | 論文
- カンジダのバイオフィルム産生性に対する抗真菌薬の効果
- 当院における全身麻酔下手術中に使用された抗菌薬の15年間(1992-2006年)の推移
- 「顎骨骨髄炎に対する抗菌薬の効果判定基準」の解析結果
- 植物精油の口腔微生物に対する抗菌性およびバイオフィルム形成抑制効果の検討
- ニフェジピン歯肉増殖症患者の線維芽細胞に対する18α-グリチルレチン酸のアポトーシス誘導効果