Clinical and bacteriological study of cefdinir(CFDN) in treatment of odontogenic infections.

概要

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Cefdinir was administered in a oral dose of 100 mg three times a day to 55 patients with odontogenic infections to investigate the clinical and bacteriological effects. The overall clinical efficacy rate of cefdinir was 89.1 %, 92.7 % (38 of 41 patients) for periodontitis and 83.3% (10 of 12) for pericoronitis. Of these patients, 5 had diabetes. Cefdinir was effective in 4 patients. The bacteriological effect was obtained as follows : The eradication rates were 84.0% (42 of 50 strains) for oral streptococci, 88.2% (15 of 17) for Peptostreptococci, and 100% (14 of 14) for Gram negative anaerobe bacilli (Prevotella, Porphyromonas, Fusobacterium) . The eradication rates were 83.6% for all the aerobic bacteria and 90.6% for the anaerobic bacteria. The clinical efficacy and bacteriological eradication rate in this study was confirmed to be nearly the same as those obtained when cefdinir was marketed in 1991.
日本歯科薬物療法学会の論文