Clinical study on concentration of lenampicillin(LAPC) in jaw cysts.

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The clinical analysis for ABPC concentration of serum, cyst wall and cyst fluid were mea-sured 1, 2, 3 and 5 hours after P. O. administration of lenampicillin (LAPC) 500 mg to 20 patients with jawcysts. Results 1. The mean peak ABPC concentration in serum was 3.41μg/ml at 2 hours after administration of LAPC, and the mean ABPC concentration in serum rapidly decreased to 0.25μg/ ml at 5 hours. 2. The mean peak ABPC concentration in the cyst wall was 0.88μg/g at 1 hour after administration of LAPC, and the mean ABPC concentration in the cyst wall gradually decreased to 0.10μg/g at 5 hours. 3. The mean peak ABPC concentration in cyst fluid was 0.90μg/ml at 1 hour after administration of LAPC, 0.13μg/ml at 2 hours, and 0.15μg/ml at 5 hours. 4. The means of ratios of the cyst wall to serum were in the range of 16.9 to 43.3%, and ABPC concentrations in the cyst wall were lower than those in serum. 5. The means of ratios of cyst fluid to serum were in the wide range of 9.9 to 52.3%, and ABPC concentrations in cyst fluid were lower than those in serum except 2 cases.
日本歯科薬物療法学会の論文