Transient bacteremia after tooth extraction using ampicillin intravenously.

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We have already reported that the incidence of transient bacteremia immediately after tooth extraction without prophylaxis of antimicrobial agent was as high as 69.2%.1) The following is our report of using ampicillin as a prophylactic by intravenous drip infusion before starting oral surgical procedure or tooth extraction. The administered ampicillin was ei-ther 500mg or 1000mg depending on the length of time required for the procedure. The drip in-fusion of ampicillin was completed within 15 or 30 minutes. While the surgical procedures were still under way, lOml of venous blood was collected. This blood sample was divided into two. One part was cultured in Bactec NR16A® and the other in NR17A® (Beckton Dickinson & Co.) . These blood culture media contained resin which quickly attached to the antimicrobial agent in the blood and neutralized the activity of the antimicrobial agent. The positive rate of blood culture was 4.3%, one out of tested 23 cases.
日本歯科薬物療法学会の論文