Pharmacokinetics of cefdinir, a new oral cephalosporin, in to oral tissues of experimental infected rabbits.

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The experimental infected models in the mandible of rabbits according to the Satoh-Heimdahl method were administered oral cephalosporin; cefdinir, dosage of 20 mg/kg. The transfer to serum and the oral tissues, including gingiva, submandibular lymph node, parotid gland, mandibula and maxilla, were examined and studied by the pharmacokinetics. 1) In the infected group, the time (Tmax) taken to reach the maximum drug concentrations in the examined tissues was 0-26 minutes later than that of serum concentration, and the maximum concentration (Cmax) of CFDN in tissues was about 17-26 % of that in serum. Meanwhile, in the healthy group, Tmax in the tissues appeared 10-23 minutes after that of serum concentration and Cmax was 16-27 % of that in serum. 2) CFDN concentrations in tissues and serum were about 1.1-1.6 times higher in the infected group than in the healthy group. And also Tmax was reached 12-44 minutes faster in the infected group than in the healthy group, 3) Comparatively good transfer of CFDN into the pus was observed in experimental lesion, although Tmax in the pus was 6 minutes later than in the serum, and Cmax in the pus reached 55 % of serum concentration.
日本歯科薬物療法学会の論文