Comparative effects of diltiazem and nicardipine on heart rate variability of patients under general anesthesia.

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We used spectral analysis of heart rate variability (HRV) to study the effects of calcium channel blockers diltiazem and nicardipine on the sympathetic nervous activity.<BR>Energy in the low-frequency range (0.04 to 0.12Hz) in supine position was used as a quantitative index of sympathetic nervous activity.<BR>Ten male patients were studied. Four patients were received diltiazem 10mg ; six patients were received nicardipine 0.5mg. HRV and arterial blood pressure were recorded 10 min before injection and 10 min after injection.<BR>The systolic blood pressure and diastolic blood pressure were both reduced after injection of either drugs. Diltiazem significantly reduced low-frequency range, but nicardipine revealed no obvious changes. There results suggest that diltiazem may reduce sympathetic nervous activity.
日本歯科薬物療法学会の論文