The basic study on dissolution behavior of dental drugs.
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概要
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We investigated the release behavior of dental drugs by dissolution test in artificial saliva. This knowledge is impotant for judging their medical effects.<BR>The commercial dental drugs studied were nine kinds of troches, five kinds of ointments, four kinds of dental corns and a few others. The dissolution test was modified from the paddle method of JPXI. The dissolution solutions used both artificial saliva I (I) of only inorganic salts and artificial saliva II (II) with inorganic salts and CMC-Na.<BR>The 50% dissolution time of troches at I was 5 min-more than 120min and we found large differences among each of the brands. The dissolution of dental ointments at I could not be observed except for Periocline<SUP>®</SUP> and showed the greatest rate of 60% at II. All dental corns were dissolved completely within 30 min at I.
- 日本歯科薬物療法学会の論文
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