Pharmacokinetic evaluation of Fluconazole. Clinical study of the relations between blood and saliva concentration.:—Clinical study of the relations between blood and saliva concentration—

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Fluconazole, a triazole antifungal agent, was studied for its pharmacokinetics and reliability for therapeutic drug monitoring (TDM) . The results obtained are as follows, 1) The blood and saliva concentrations of Fluconazole after oral administration ran parallel and were almost equal. 2) When an oral dose of 200 mg Fluconazole was administered, saliva concentration reached 75 % Inhibitory concentration (IC75) for almost all oral candida activities, and especially for Candida albicans it reached a comparable result as from an oral dose of 100 mg Fluconazole. 3) Saliva concentration is similar to that of the blood level, thus, this indicates that the saliva concentration is a reliable measure for TDM.
日本歯科薬物療法学会の論文