Clinical observation on drug fever induced by parenterally administered antibiotics in oral and maxillofacial surgery.

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The incidence and clinical features of drug fever caused by antibiotics were investigated by analyzing the inpatients treated with antibiotics of parenteral use in the field of oral and maxillofacial surgery during the past 5 years. 1) Of a total of 576 cases, drug fever was found in 4 cases (0.7 %) . 2) Latamoxef (LMOX) induced drug fever in 1 out of 117 (0.9 %), cefotaxime (CTX) in 1 out of 69 (1.4 %) and piperacillin (PIPC) +cefazolin (CEZ) in 2. 3) Drug fever occurred on 1st, 3rd, 11 th and 14 th day. The type of fever was cassified as gradual onset type in 2 and cataplectic type in 2. The grade of fever was 38.2-39.0°C.The fever subsided within 1 to 3 days after drugs administration was terminated. 4) From these laboratory findings, a transient decrease in the number of leukocytes was found in 2 cases, eosinophilia in 1 case, a slight decrease in the number of platelet in 1 case and a transient elevation of alkaline phosphatase, glutamic oxaloacetic transaminase, glutamate pyruvate transaminase and lactate dehydrogenase level in 1 case. However, no definite trend was recognized. Further clinical examination has stown different disorders as well as different clinical manifestations. Therefore it is important to observe carefully the patient's clinical process in making diagnosis such as drug fever.
日本歯科薬物療法学会の論文