Comparative clinical study of Cefteram pivoxil (CFTM-PI) with Cefaclor (CCL) in the treatment of odontogenic infections.
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The clinical efficacy, side effects and clinical usefulness of Cefteram pivoxil (CFTM-PI) were compared with dose of Cefaclor (CCL) by a double-blind method in the treatment of oral infections. Since the need explanation, what does it mean by test compound were odontogenic antibacterial agents, the target diseases were limited to periodontal infections, pericoronitis and osteitis of jaw. Drugs were administered for 3-7 days at doses of 200mg t, i. d. (CFTM-PI) and 250 mg t.i.d. (CCL) . A total of 248 cases were included in this study.<BR>Results obtained were as follows:<BR>1) The clinical efficacy was evaluated by the doctors-in-charge in 245 cases (123 in the CFTM-PI group and 122 in the CCL group) and the numerical rating on the 3 rd day of treatment in 245 cases (123 in the CFTM-PI group and 122 in the CCL group) .<BR>The clinical efficacy rate according to the doctors-in-charge was 84.5 % for the CFTM-PI group and 79.5 % for the CCL group. The evaluation of the numerical rating was 88.7 % for the CFTM-PI group and 80.9 % for the CCL group.<BR>There was no significant difference found in tems of clinical effectiveness between the two groups by using these two methods of clinical diagnosis.<BR>2) Some side effects were discovered in 5 cases (4.1 % of 122) treated with CFTM-PI and in 4 cases (3.3 % of 120) treated with CCL, but no severe symptoms were observed. Abnormal changes found in the laboratory were noted as 9.1 % in the CFTM-PI group and 14.5 % in the CCL group.<BR>There was no significant difference in terms of safety between the two groups.<BR>3) Similarly, in terms of clinical usefulness, there was no significant difference between these two groups.<BR>From these results, it is concluded that CFTM-PI is as effective as CCL in the treatment of odontogenic infections.
- 日本歯科薬物療法学会の論文
日本歯科薬物療法学会 | 論文
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