The change of the immunological functions of cancer patients with the administration of interleukin-2

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概要

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• Interleukin-2 (IL-2) was administrated to three cases of progressive oral cancer, and the immunological activities were observed.<BR>Case 1: A 77 year-old man with recurrent squamous cell carcinoma of the buccal mucosa.2.59×10<SUP>7</SUP>JRU (Japan Reference Unit) of IL-2 was injected into the tissue surrounding the tumor for 24 days. The regression of the tumor was observed, and was considered to the partial response (PR) . However, the tumor made progeress and the patient passed away after 4 years.<BR>Case 2: A 62 year-old woman with progressed squamous cell carcinoma of buccal mucosa. 7.7×10<SUP>6</SUP>JRU of IL-2 was injected intravenously for 11 days. The tumor made progress despite the radiation and chemotherapies, the patient underwent and she passed away after 2 months.<BR>Case 3: A 63 year-old man with squamous cell carcinoma of maxillary sinus. After 3 weeks of partial resection of the maxilla the residual tumor was observed on the pterigoid fossa. 1.5×10<SUP>7</SUP>JRU of IL-2 was administrated intravenously with<SUP>60</SUP>Co radiation. The patient has been living without tumor since 1988.<BR>The number of eosinophilic leucocytes were increased in case 1, and the number of total lymphocytes were increased in cases 1 and 3. Some kinds of phenotypes of lymphocytes were in high level in case 2, however they were not increased after treatment. In cases 1 and 3, CD 57 and CD 16 positive cells were increased after the administration of IL-2, and NK and LAK activities were also increased.

• 一般社団法人 日本口腔腫瘍学会の論文

一般社団法人 日本口腔腫瘍学会 | 論文

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