A case in which multiple primary cancers at different periods on lower gingiva and tongue appeared, 2 years after diagnosis of multiple oral leukoplakias.

概要

論文の詳細を見る
We reported one case, in which, malignant transformation during follow-up in terval for leukoplakia, occured twice. On 2/20 1986, multiple lesions of leukoplakia existed on right upper gingiva as well as right lower gingiva, palate and right glossal border. One week later, the reversible leukoplakia lesions on right upper gingiva and palate were healed, but the leukoplakia of left glossal border appeared. On 4/3, incurable lesions of leukoplakia, of which the pathologic status was dysplasia, were excised, including safty margin. However, one month after the excision, leukoplakia recurred but was soon made less serious by the medication of UFT. On 10/14, treatment by our clinic was given up halfway, because of the general condition, in spite of the new emerengence of lower lingual gingival leukoplakia. On 11/17 1988, When the patient came to our clinic again, the squamous cell carcinoma (T1N0M0) was appeared. Partial resection practised on 12/14, after preliminary chemotherapy. At though it had been making satisfactory progress without reccurence, the squamous cell carcinoma on the right glossal border showed up in the back of leukoplakia of the same on 6/13 1991. By means of the neo-adjuvant chemotherapy and later radical therapy by interstitial irradition of <SUP>137</SUP>Cs needle, this lesion disappeared. Presently, we are cautious to reccurence and new appearance of malignant tumors.
一般社団法人日本口腔腫瘍学会の論文