Combined Preoperative Treatment with Intraarterial Chemotherapy (Cisplatin+Peplomycin) and Radiotherapy in the Head and Neck Cancer.

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For appraisal of preoperative treatment, the effects of combined intraarterial chemotherapy and radiotherapy were evaluated in previously untreated patients with squamous cell carcinoma of the head and neek (experimental group) . The experimental group consisted of 14 patients who received both 60Co-radiotherapy (20-30Gy) and intraarterial injection of cisplatin (20 mg/m2/week ×2) and peplomycin (5 mg/body/day×10) before surgery. Ten analogous patients who had received only radiotherapy (20-34Gy) preoperatively in our clinic were used as the control group. Patients in both groups received a radical resection of the tumor 7 to 10 days after the preoperative treatment. Histological findings of the resected materials were compared in each group. Effectiveness (more than Grade II A in Oboshi's classification) of the preoperative treatment was revealed in significantly greater number in the experimental group (79 %) than in the control group (30 %) . However, some adverse effects such as loss of hair and stomatitis were also significantly greater in the experimental group, but subsided soon after discontinuance of the chemo- or raidotherapy. Moreover, it was suggested that stomatitis, the most frequent adverse effect, could be significantly minimized without disturbing the therapeutic effects, when the dose of radiation was maintained at 20Gy.
一般社団法人日本口腔腫瘍学会の論文