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Chemoradiation, targeted intraarterial infusion of Carboplatin (CBDCA) plus irradiation, was performed in patients with oral squamous cell carcinoma (Oral SCC) . Forty-three patients with Oral SCC were analyzed in terms of the expression of side effects. Dose of CBDCA was determined by Calvert's formula (AUC 4.5) . Total dose of radiation was 30 Gy, which consisted of 2 Gy/day 5 times per week, or 1.5 Gy twice a day 5 times per week. The patients were 33 males and 10 females, ranging between 30 and 86 years of age. The total dose of CBDCA ranged from 260mg to 740mg. Allopurinol gargle or poraprezinc-sodium alginate suspension was applied to prevent radiation and/or chemotherapy induced stomatitis, and Ancer 20 injection was administered by subcutaneous injection. Most patients had erythrocytopenia, leukocytopenia, thrombocytopenia, dermatitis and stomatitis. Especially, stomatitis was recognized in all patients. According to WHO criteria, 6 cases had grade 3 stomatitis, and only one case had stopped X-ray irradiation because of severe stomatitis.
一般社団法人日本口腔腫瘍学会の論文