A cell diversity of oral squamous cell carcinoma in diagnosis of malignancy

概要

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As malignancy expression of the cancer cell, First, Atypia of tumor cell or tissue polymorphism are strong. Second, the tumor cells were high growth ratio and that it destroys the tissue in the tumor circumference. Third, it is mentioned that the metastasis is formed. For example, increase and heterogeneity of the nuclear chromatin are observed as the matter exchange or reflection of the abnormal interaction between nucleated cell quality, and as the result, the abnormality of the protein synthesis process appears. It tries to make the increase in the nucleolus to be a result of accentuation and much quick turnover of RNA the approach of the cell proliferation. Simultaneously, the mitosis indicates the accentuation when it makes cell proliferation, modulation in cell cycle, and generation of chromosomal abnormality. The cell becomes malignant like this, and by acquiring the proliferation capability, various expressions appear in the cell. In this study, immunohistochemical analysis and genetic analysis of cancer cell were carried out, and various malignancy of the cancer cell was searched.<BR>As the result, it was indicated that to search the phenotype of the malignancy in cell proliferation area of the carcinoma tissue was important.
一般社団法人日本口腔腫瘍学会の論文