Effects of Experimentally Accelerated or Inhibited Eruption of Rat Incisors on Tooth Formation and Maxillary and Craniofacial Bone Growth.
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In the present work, we examined histologically the effects on enamel and dentin formation of rat upper incisors, as well as on growth and modeling of maxillary and craniofacial bones, by modulation of incisor eruption. Male SD-rats (200g b. w.) were used. The animals were divided into three experimental groups: (1) unimpeded or accelerated eruption by cutting the incisor edge twice a week throughout the experimental period; (2) pinning the incisors to completely prevent eruption: and (3) impeded eruption as control. Fluorescent labelings were given two or three times at 7-day intervals prior to sacrifice of the animals. At the end of the 4-week experimental period, resin-embedded cross-sectional ground sections were prepared from the individual incisors and from three regions of the skull corresponding to premaxillarynasal, frontal-maxillary and parietal-squamosal planes. On the basis of macroscopic and histologic examination, histomorphometric analysis, and elemental analysis, it was found that: (i) kinetic aspects of enamel and dentin formation were markedly affected by either acceleration or prevention of tooth eruption, but there were no marked changes in either the quantity or mineralization of the mature enamel; (ii) the alveolar bone surfaces facing the unimpeded or pinned incisors continued active modeling and remodeling in a comparative manner as observed in the control group; (iii) pinning the incisor gave rise to an upward dislocation of the pinned tooth in the alveolar socket and a distorted appearance of premaxillary bones, but no further effects by the disturbed incisor eruption were ascertained on the contour and structure of bones in the craniofacial regions.
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