Remineralization Effect of Xylitol Chewing Gum Containing Gloiopeltis furcata Extract and Calcium Hydrogenphosphate on Initial Caries-like Enamel Lesions.
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概要
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The objective of the present study was to investigate the beneficial effects of xylitol chewing gum containing <I>Gloiopeltis furcata</I> extract and calcium hydrogenphosphate on remineralization of initial carieslike enamel lesions. Initial caries-like enamel lesions were artificially prepared by demineralizing human enamel blocks with a 0.01M acetate buffer (pH 4.0) at 50°C. We investigated sucrose gum (control), xylitol gum, and xylitol gum containing G. <I>furcata</I> extract and calcium hydrogenphosphate. In the <I>in vitro</I> intvestigation, the enamel blocks having initial caries-like enamel lesions were immersed in a remineralizing solution containing the extract of each chewing gum at 37°C for 2 weeks, and then evaluated for degrees of remineralization by contact microradiography. The remineralizing potential of each chewing gum <I>in vivo</I> was also evaluated by an oral device fixed with artificially demineralized human enamel block. Each subject was fixed on this device on the lingual surface of the mandibular molar for one week, and was given chewing gum samples 7 times a day. This <I>in vivo</I> study was carried out by the double-blind method.<BR>It was found that xylitol gum enhanced the remineralization of initial caries-like enamel lesions, and that xylitol gum containing <I>G. furcata</I> extract and calcium hydrogenphosphate promoted the action of xylitol gum on remineralization. These findings suggest that adding <I>G. furcata</I> extract and calcium hydrogenphosphate to xylitol gum can amplify the remineralization effect of xylitol and can be expected to be effective in reducing dental caries.
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