Functional Significance of Pyrophosphate in Discrete Forms in Mineralizing Milieus.
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概要
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The current work aimed to gain a better insight into the molecular states and functional significance of pyrophosphate ions (PPi) in media assimilated to human saliva. PPi exhibited complete inhibition of apatite crystal growth in a concentration range of 10-6M or higher. Experimental data also showed that PPi at corresponding concentrations could evoke precipitation of calcium pyrophosphate dihydrate (Ca<SUB>2</SUB>P<SUB>2</SUB>O<SUB>7</SUB>·2H<SUB>2</SUB>O) in the presence of 1mM Ca<SUP>2</SUP>, giving rise to the loss of inhibitory activity. Fluoride at concentrations around 1ppm counteracted the inhibition of apatite precipitation by PPi. It is conceivable that increasing the driving force for apatite growth after fluoride addition allowed a growing step to squeeze between the adsorbed PPi molecules and then bury them in the lattice. On the basis of currently available information, we propose a delineated model to explain the behavior of PPi at the crystalsolution boundary in mineralizing milieus.
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