Histological study on the submandibular gland in rats fed a pancreatin-mixed diet, and the effects of lingual nerve resection.

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Histological changes in the rat submandibular gland acinar cells after the intake of pancreatin with or without gustatory nerve resection were investigated by means of light and electron microscopy. A powdered meal mixed with pancreatin at a dose of 4% by weight was given to Sprague-Dawley rats.<BR>A marked increase in size of the acinar cells was observed even in the animals without nerve resection, fed the pancreatin-mixed diet for a week. Almost all the secretory granules present in the acinar cells changes into granules with a core-like structure, which seemed to contain mucopolyssacharides. Two weeks after cessation of pancreatin feeding, the acinar cells were slightly decreased in size, but returned to their original size at three weeks. In the rats whose bilateral lingual nerves were resected at the base of the tongue to reduce the sense of taste, the acinar cells increased in size more notably than in those without lingual nerve resection. In addition, the animals in the former group excreted saliva to excess. Although the reason why the acinar cells became larger in the animals fed the pancreatin-mixed diet after lingual nerve resection is not clear, pancreatin in the blood may act on the submandibular gland and lingual nerve resection may impair the function of the autonomic nervous system innervating the submandibular gland.
歯科基礎医学会の論文