IL-1 and TNF production from mouse osteoclasts induced in coculture system.
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概要
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IL-I and TNF are bone resorptive cytokines whichare key elements in th e proinflammatory cytokine cascade that is activated in response to infection. Here, we determined the production of IL-lα, IL-1β and TNFα, TNFβ from mouse osteoclasts in the coculture system. The production of cytokine from osteoclasts was examined by immunohistochemistry and <I>in situ</I> hybridization. In the coculture system of C57BL/6N mouse bone marrow cells and MC3T3-G2/PA6 cells, the colony of osteoclasts were formed after 7 days of culture and IL-la and TNFa were detected in the osteoclast. However IL-β and TNFβ were not detected. In the MC3T3-G2/PA6, these cytokines were not detected. These findings suggested that local production of IL-lα and TNFα by osteoclasts may be an important mechanism for regulating the bone resorption.
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