Cytokine production and bone resorption by osteoclast appearing in periapical lesion of rat model system.

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Periapical bone destruction is an important pathogenic sequellum of pulpal infecti on, and interleukin1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of apical periodontitis. The relationship between the bone destruction and appearance of osteoclasts were investigated in developing ratperiapical lesions. Furthermore, bone resorptive cytokines (IL-1α, TNF α) produced by osteoclasts were analyzed. Osteoclasts appeared beginning on day 2 and increased on day 7. The kinetics of bone destruction was almost in parallel to the appearance of osteoclast after pulp exposure. IL-lα and TNFα were both detected on the osteoclasts. By contrast, production of IL-1β and TNFβ was not found by immunohistochemical techniques and in situ hybridization. These findings demonstrate that IL-lα and TNFα are produced from osteoclast in developing periapical lesions of rat, and these mediators play keyroles in periapical destruction.
歯科基礎医学会の論文