Morphological studies on the regeneration of rat submandibular gland following YAG laser irradiation.

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The purpose of the present study was to investigate the regenerative process of salivary gland. 163 male Wistar rats of 7 to 8 week-old were used. After YAG laser irradiation to injury to the submandibular gland, regenerative changes that occured were then observed morphologically.<BR>The irradiated region showed an area of necrotic tissue which soon acquired a gradually increa-sing amount of granulation tissue along its periphery. Duct-like structures remaining in the granulation tissue were noted and observed to form epidermoid cell nests with high proliferative activity. Electron microscopically, the epithelial cells of epidermoid cell nest and duct -like structure were observed to consist of two cell types; an inner clear cell and an outer dark cell. Inner clear cells showed tendencies to differentiate into duct epithelial cells. In addition, differentiation into striated duct cell, intercalated duct cell, immature acinar cell, and myoepithelial cell were observed when the lobular structure was newly formed.<BR>These findings suggest that locally damaged salivary gland possesses active capacity for regeneration and that the regeneration process of salivary gland originates from the remaining duct-like structures around the necrotic tissue which proliferate and differentiate into the various components of the salivary gland.
歯科基礎医学会の論文