Immunohistochemical localization of ras p21 in ameloblastoma.
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概要
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The expression of <I>ras</I> p 21 and its histological localization on 13 ameloblastomas has been immunohistochemically studied using monoclonal antibody NCC-RAS-001 as the primary antibody. The <I>ras</I> p 21 was detected in 10/13 (76.9%) ameloblastomas; 3/5 (60.0%) were of the follicular and 7/8 (87.5%) of the plexiform type. In addition, <I>ras</I> p 21 was also detected in the cytoplasm of metaplastic squamous cells. The result suggested that <I>ras</I> p21 may be closely related to the proliferation and the development of tumor cells in ameloblastoma.
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