Morphological and biochemical studies of induced tumors of the rat submandibular gland.

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Morphological and biochemical studies were made to examine whether and rogen is responsible for the properties of submandibular tumor. The tumor was induced with carcinogenic hydrocarbon, 9, 10-dimethyl-1, 2-benzanthrasen, in Fisher rats. Alkaline esteroprotease and 5α-reductase were biochemically measured and the morphological observations made with a light microscope.<BR>The histological structure of all of the experimental submandibullar gland tumors showed the pattern of a well differentiated squamous cell carcinoma with keratin being formed with in the neoplasm. Neither adenocarcinoma nor metastic lesions are created under the conditions of the present experiments. Alkaline esteroprotease from the tumor was very lower in activity than that from the control, when measured in tissue homogenates.Microsomal 5α-reductase activity in the tumor was conversely much grater than that in the control.<BR>These results suggest the possibility that and rogen may play a role for the growth of the carcinogeninduced rat submandibular gland tumor.
歯科基礎医学会の論文