An electron microscopic study of collagen degradation by the fibroblasts in sound dental pulp of rhesus monkey (Macaca mulatta).
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The purpose of this paper is to report the occurrence of the phagocytosis of collagenfibrils by fibroblasts in the sound dental pulp. The materials used were lower second molar pulps ofa five-year old rhesus monkey (<I>Macaca mulatta</I>) which was killed by perfusion with a 1.25% glutaraldehyde-0.75% paraformaldehyde fixative. The molars were dissected out of the mandible, demineralizedin EDTA and embedded in epoxy resin for ultrasectioning. The observations were focussedprimarily on the fibroblasts which were distributed in the cell rich zones and central regions of thepulps. The sections cut were observed with an electron microscope after staining with uranyl acetate and lead citrate.<BR>Collagen-containing bodies, varying in diameter from 0.05μm to 0.3μm, were frequently observedwithin the fibroblasts. When they occurred in the cytoplasmic processes, the bodies showed elongateprofiles, and contained collagen fibrils with the typically banded structures. In the bodies which appearedto be more centrally placed in the cells, the banded structures were vague or impossible to see onthe collagen fibrils which were surrounded by electron dense material. Fusion of lysosomal granuleswith the collagen-containing bodies could be seen in some cases. These observation indicate that thefibroblasts in the pulps are involved in the phagocytosis and degradation of collagen fibrils, a functionwhich has also been observed in the periodontal ligament and gingiva.
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