Secretory pattern of characteristic glycoprotein species from segments of the rat submandibular gland following methoxamine stimulation.

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It is recognized that the rat submandibular gland consists of five distinct parenchymal segments, acini, intercalated ducts, granular ducts, striated ducts and excretory ducts, and the function of these segments are different from each other. These parenchymal components can be separated from salivary glands of the rat following a microdissection method devised by us.<BR>Using these dissociated preparations and electrophoretic techniques, we found that the functional segments of the submandibular gland of intact rats contain several glycoprotein species; some of these have a characteristic response to stimulation and are secreted into submandibular saliva in a diffel ent manner depending on the kind of drug, such as, cholinergic agonists and aor β-adrenoceptor agonists.<BR>The present study was designed to observe the secretory pattern of these characteristic glycoprotein species in acini and convoluted granular tubules following stimulation by methoxamine, because such observations have not yet been reported. For this purpose, changes in the salivary flow rate and the composition of glycoprotein species were followed during salivation induced by an aladrenergic agonist, methoxamine.
歯科基礎医学会の論文