Effects of adrenergic agents on glycoprotein secretion from acini and granular convoluted tubules of the rat submandibular gland.

概要

論文の詳細を見る
The rat mandibular gland is known to contain two major types of secretory cells: acinar cells and cells in granular convoluted tubules. Abe and Dawes have postulated in their electrophoretic study of submandibular saliva that some kinds of characteristic proteins found in the saliva in response to β-adrenergic and cholinergic agonists are primarily derived from the acinar cells, whereas proteins specific for α-adrenergic agonist stimulus are mainly derived from the granular convoluted tubules.<BR>In the previous study, glycoprotein species in parenchymal components dissociated from submandibular glands of normal adult rats were analysed micro-electrophoretically and it was shown that acini and granular convoluted tubules differ markedly in the number of glycoprotein species and in the amount of glycoprotein per protein. In addition, we reported that characteristic glycoproteins which were secreted in response to a cholinergic agent, pilocarpine, were primarily derived from acinar cells.<BR>The present study was designed to elucidate the action site of some α- and β-adrenergic agents on the rat submandibular gland by following up characteristic glycoprotein species found in acini and granular convoluted tubules with the aid of SDSmicro electrophoretic techniques. The results described here support the view that β-adrenergic agents act on acinar cells and α-adrenergic ones on granular convoluted tubules.
歯科基礎医学会の論文