Immunohistochemical studies on salivary gland tumors. III. Localization of secretory epithelial markers in various malignant tumors.:III. Localization of secretory epithelial markers in various malignant tumors
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Amylase (AM), lactoferrin (LF), lysozyme (LY), and secretory component (SC) were studied in 61 cases of malignant salivary gland tumors (acinic cell tumor 3, mucoepidermoid tumor 13, adenoid cystic carcinoma 18, adenocarcinoma 7, malignant mixed tumor 4, malignant myoepithelioma 2, and undifferentiated carcinoma 14) using the peroxidase-antiperoxidase method.<BR>Since LF and SC were frequently detected in most tumor types other than undifferentiated carcinoma and malignant myoepithelioma, often in corresponding tubular cells in serial sections, it was suggested that the combined findings of these two markers might represent a universal indication for glandular differentiation of the malignant tumor cells, particularly toward the intercalated duct. AM was revealed in abundance not only in acinic cell tumor but also in mucoepidermoid tumor and less frequently in some other tumor types, and was regarded as a useful marker for serous cell differentiation of the tumor cells. These three secretory proteins were also demonstrated in a few cells of undifferentiated carcinoma, suggesting functional differentiation of the morphologically undifferentiated cells toward secretory epithelium.<BR>In conclusion, an immunohistochemical demonstration of AM, LF and SC seems to provide helpful information for estimation of secretory epithelial differentiation of the neoplastic cells in malignant salivary gland tumors. It is also likely that this approach can be useful for diagnosis and/or subclassification of such a group of salivary gland tumors showing an undifferentiated morphological pattern.
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