Biosynthetic regulation of proteinase F by various hormones in the mouse submandibular gland.

概要

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Different from most of other proteinases such as proteinase A, D and P in the mouse submandibular gland, proteinase F is rich in the gland of female mice. The in vivo biosynthesis of proteinase F was inhibited by androgen in males but not in females. The lack of response to androgen in adult females seemed to be due to the lack of the exposure against unknown factor (s) supposed to be secreted from the testis of new born mice. The in vivo inhibition of proteinase F biothynthesis by androgen in adult males appeared to require the presence of the thyroid gland, which may secrete some inhibitory factor (s) in response to androgen: whereas the pituitary gland may secrete certain substances (Pituitary factors) which stimulate the proteinase F biosynthesis. The androgen stimulated the biosynthesis of proteinase F in the hypophysectomized mice which are also hypothyroid. Therefore, androgen is thought to be stimulatory in the absence of both the pituitary factor (s) and thyroid factor (s).
歯科基礎医学会の論文