:with special reference to the ability of monoamine precursor-uptake

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The taste buds in ICR mouse after bilaterally sectioning the gas tatoty nerves, followed by administration of monoamine precursor (5-HTP, L-DOPA), were investigated with light and electron microscopy as well as by fluorescent histochemically applying the Falck-Hillarp method.<BR>Degeneration of the taste buds was seen conspicuously by the 7th postoperative day and virtually all taste buds were lost by the 10th day. The gastatory (type III) cells under degeneration, however, kept the ability of monoamine precursor-uptake.<BR>Regenerating taste bud cells originated from the epithelial basal cells which were in contact with the terminal of the reinnervating nerve by the 14th day. In the early stage of regeneration of the taste bud, immature gastatory (type III) cells had monoamine precursor-uptake ability.<BR>These results indicate that the gastatory nerves are essential for differentiation and integration of the structure of a taste bud. Further, they strongly suggest that the gastatory (type III) cells obtain monoamine precursor-uptake ability at a very early stage of regeneration, and that the uptake ability persists even in the denervated gastatory cells.
歯科基礎医学会の論文