Immunopathological study of periodontal disease Localization of bacterial chondroitinase ABC and hyaluronidase in the gingiva of individuals with periodontal disease.:Localization of bacterial chondroitinase ABC and hyaluronidase in the gingiva of individ

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The purpose of this investigation was to study the presence of bacteria chondroitinase ABC and basterial hyaluronidase in inflamed human gingiva by a fluorescence antibody technique. The presence of chondroitinase ABC was demonstrated in all of 30 cases and hyaluronidase was detected in 21 cases. Both enzymes existed on the surface of gingival epithelium, in the epithelium, in the subepithelial connective tissue and in the cytoplasm of phagocytes. The existence was mainly in the sulcular portion. The tissue or cells in which the enzymes localized suffered from destruction such as degenera-tive, atrophic and/or necrotic changes, and widened intercellluar spaces were also observed in the sulcular epithelium.<BR>From the above results, it was indicated that chondroitinase ABC and hyaluronidase, produced in dental plaque, penetrated from the surface of gnigival epithelium by hydrolysing acid mucopolysacchalide in the space of epithelium to supepithelial connective tissue and initiated periodontal disease.
歯科基礎医学会の論文