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The effect of epidermal growth factor (EGF) on clone MC3T3-E1 cells which have osteoblastic ability was examined morphologically and biochemically. The addition of EGF (0.4-50 ng/ml) to the culture dishes transformed the cells from their normal polygonal shape into a spindle-like morpho-.ogy. Cell transformation began after 8 hours following the addition of 10 ng/ml EGF. This hormone caused a significant stimulation of cell growth and increased the protein content of the cells at 2, 10 and 50 ng/ml. However, the same doses of EGF significantly reduced the hydroxyproline content. The addition of anti-EGF to EGF-containing cultures completely blocked such morphological and biochemical changes caused by EGF. EGF (10-50 ng/ml) caused a significant inhibition of collagen synthesis of the cells. Protein synthesis was stimulated by the same doses. and, as a result, the proportion of collagen to protein synthesis markedly decreased with increasing EGF concentration.
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