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Dentin permeability of endodontic therapeutics such as formalin, formalin tricresol, 10 % paraform propylene glycol solution, phenol, Black's preparation, camphophenique, campholated phenol and modified phenol were studied in reference to their vaporization rate at 37°C. Paper points which contained a constant volume of each drug were applied to the enlarged root canals (hand reamer, No.10-60) of extracted human teeth, and then the root apex and the coronal portion of the endodontic cavity were tightly sealed with carboxylate cement. The tested teeth immersed in 30 ml distilled water were incubated at 37°C for a constant time and the amount of formaldehyde and phenol permeated into the water through the dentin was determined. Vaporization rate of formaldehyde and phenol was also tested with the same drugs. The results were as follows: 1) Formalin, formalin tricresol and 10 % paraform propylene glycol solution, in that order, diffused formaldehyde into distilled water. 2) Phenol, Black's preparation, camphophenique, campholated phenol and modified phenol, in that order, diffused phenol into distilled water. 3) A close correlation between vaporization rate and dentin permeability was observed. The present results suggest that both the vaporized molecules of formaldehyde and phenol in the root canals diffuse into the dentinal tubules easily.
歯科基礎医学会の論文