Role of the motility of gastrointestinal tract in acetic acid induced writhing syndrome

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In order to elucidate the mechanisms of writhing syndrome induced by intraperitoneal injection of acetic acid in mice, a study was made in relation to the motility of gastrointestinal tract.<BR>Judging from the facts that the inhibition of the passage of charcoal meal in digestive tube, the relaxation of isolated intestine and the decrease of excretion of stool, the marked inhibition of the motility of gastrointestinal tract in acetic acid induced writhing mice were recognized. Furthermore, a close relationship between the motility of gastrointestinal tract and stretching movement was observed.<BR>α-Adrenergic blocking agents such as tolazoline, phentolamine, dibenamine, phenoxybenzamine and hydergine inhibited stretching movement strongly in conjunction with recovery of depressive motility of gastrointestinal tract in writhing mice. The stretching movement was inhibited markedly by serotonin (s. c.) administration and facilitated by dopamine (s. c.) administration. While 35 % of the decrease of total catecholamine contents of gastrointestinal tract was observed at 1 hour after administration of acetic acid intraperitoneally.<BR>These suggest that adrenergic system is concerned with the motility of gastrointestinal tract, and which is very important factor in writhing syndrome.
歯科基礎医学会の論文