Studies on the Tawa sarcoma. VIII.:The growth form and cyto-biological characteristics of tumor cells

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The growth form and cyto-biological characteristics of Tawa sarcoma were studied, using Donryu rats transplanted intraperitoneally with 107 cells of the Tawa sarcoma. The results obtained were as follows: 1) During the first four days after transplantation the tumor cells showed an almost logarithmical increase followed by the same level continuing till the animals died of tumor. The tumor cells doubled in 11 to 14 hours during the logarithmical growth phase. 2) The tumorigenic ascitic fluid showed a logarithmical increase in correspondence with the logarithmical increase of cells, although the increase was rather slow during the terminal period of hosts. 3) The tumor cells growing in the ascitic fluid were 20×104/mm8, and they accounted for about 30% of the whole volume of the tumorigenic ascitic fluid. 4) Mitosis developed most markedly two to three days after transplantation proving to be as high as about 4.5%, which was suggestive of a mitotic time of 37 to 53 minutes. The mitotic rates at prophase, metaphase, anaphase and telophase were almost constantly 39%, 31%, 13% and 17%, respectively. 5) The mean diameter of tumor cells was 18μ in three to five day-old tumorigenic ascites and it showed a tendency to decrease in the initial and final phase of hosts. 6) It was concluded that the tumor cells grew most markedly with an appearance of stability in ascitic fluid three to four days after transplantation.
歯科基礎医学会の論文