Study of Hereditary Trends in the Shape of the Murine Mandible.
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概要
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Inbred mice are a suitable material for genetic studies, and mandibular shape in particular provides a highly quantitative hereditary trait. We investigated which genetic trait in F<SUB>1</SUB>, F<SUB>2</SUB> and N<SUB>2</SUB> hybrid mice was most strongly affected by the presence of a large or small mandible in the parents. Ten C57BL/6By strain mice as parents with a small mandible and 10 MRL/n strain mice as parents with a large mandible were employed. Twenty-five (C57BL/6By male × MRL/n female) F<SUB>1</SUB> and 67 F<SUB>2</SUB> hybrids, and 28 (F<SUB>1</SUB> male × C57BL/6By female) N<SUB>2</SUB> backcross hybrids were obtained by laboratory mating. The inter-landmarks of the right mandible were measured by an electronic digitizer. Each mean value of horizontal dimensions in F<SUB>1</SUB> mice resembled that in MRL/1 mice, and that in N<SUB>2</SUB> mice was intermediate between C57BL/6By and MRL/n mice. On the other hand, the mean values of vertical dimensions in F<SUB>1</SUB>, F<SUB>2</SUB> and N<SUB>2</SUB> hybrids were intermediate between those of C57BL/6By and MRL/n mice. Hence we suggest that horizontal dimensions are predominantly inherited by mice with a large mandible, and that vertical dimensions show intermediate inheritance between mice with large and small mandibles in the C57BL/6By and MRL/n strains.
- 日本大学歯学部の論文
日本大学歯学部 | 論文
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