In vivo voltammetric study of cortical 5-HT after administration of 5-HTP or paroxetine to phenelzine-treated rats.
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The effects of 5-hydroxytryptophan (5-HTP) and paroxetine on cortical extraneuronal 5-hydroxytryptamine (5-HT) in phenelzine-treated rats were studied using <I>in vivo</I> differential pulse voltammetry. Two injections of phenelzine (46.8 mg/kg 18 h and 11.7 mg/kg 90 min previously) reduced the indole oxidation current by approximately 20%, whereas a single injection (46.8 mg/kg 90 min previously) did not. Injections of 5-HTP, but not paroxetine, in phenelzine-treated rats caused an increase (71 %) in the indole oxidation current.
- 日本大学歯学部の論文
日本大学歯学部 | 論文
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