Study on the Electrical Response induced by Dopamine across the Isolated Tegumental Membrane of the Rat Submaxillary Gland
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概要
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The electrical response produced by dopamine across the isolated tegumental membrane of the rat submaxillary gland was examined by using the Ussing's flux chamber.<BR>The following results were obtained : <BR>1. As dopamine concentration increased (from 10<SUP>-5</SUP>M to 10<SUP>-2</SUP>M), the electrical responses induced by dopamine rose from 3.5mV to 10.5mV in each peak of these potential differences. These electrical responses were dependent on dopamine concentration.<BR>2. The electrical responses induced by dopamine were antagonized by pre-applying alpha-adrenergic blocking agent, priscol.<BR>3. The electrical responses induced by dopamine were antagonized by pre-applying beta-adrenergic blocking agent, propranolol.<BR>4. The electrical responses induced by dopamine were antagonized by pre-applying specific dopamine receptor blocking agent, chlorpromazine.<BR>These results suggest that there is a competitive interaction between dopamine and the antagonists (priscol, propranolol or chlorpromazine) and that alpha-, beta-adrenergic receptors and specific dopamine receptor are present in the tegumental membrane of the rat submaxillary gland.
- 日本大学歯学部の論文
日本大学歯学部 | 論文
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