A Curative Effect of Carnosine (β-alanyl-1-histidine) on the Decubital Ulcer
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概要
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An effective dose of 1-carnosine (β-alanyl-1-histidine) for the restoration of inflammatory tissues (by formalin filter method) is known to be 8.8 μmol/100g rat ip. In the present paper, an application of this potent effect to the decubital ulcer is discussed. By spraying minute powder of 1 to 3g carnosine on an ulcerous wound, the necrotic layer is made to fall off and, through the formation of new granulations, the wound will become gradually cicatrized from the periphery.<BR>Carnosine, when used in the form of spray in an amount of 1 to 3g daily, proved quite beneficial to 5 patients of the decubital ulcers of varying degree. When a case is light enough without any necrotic layer, the formation of fresh granulations took place in about 2 weeks, reaching a complete cure. The physiologic significance of carnosine in the repair of inflamed tissues is now being explicated. That carnosine corresponding to 1/35 of what is usually contained in a vital body is sufficient to repair inflamed tissues, appears to indicate that carnosine is an important chemical mediator playing a major role in this healing process.<BR>Our biochemical knowledge of carnosine alone will not solve the granular promotive mechanism on the part of carnosine and much future research is indicated in this direction.<BR>At the present state of our knowledge, it may be concluded that, along with cortisone, carnosine is significant in that it is a co-factor in the vital defense mechanism.
- 日本大学歯学部の論文
日本大学歯学部 | 論文
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