Anti-inflammatory Agents and Physiological Concepts of their Screening
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概要
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The phenomenon of inflammation is regarded, in a physiological sense, as a defense response to the maintenance of permanent functions of a living body. Thereare many oppositions to this way of looking at the inflammation. Some hold that since the inflammation is usually attended by severe injury of tissues or region in which it occurs, it can never be looked upon as a self-defense mechanism. Reference is often made to the fact that whereas the reaction of heterogeneous serum for thefirst time is slight enough, an allergic reaction the second time is far more severe.<BR>However, it is possible physiologically to reproduce an anti-body reaction <I>in vitro</I> and this reaction should be regarded as a source of physiological stimulus rather than an inflammation itself. This source of physiological stimulus in turn leads to an inflammation. The semantic use of the term 'defense mechanism' seems to suggest that there should not be any injury, explicit or otherwise. In the belief of the author, however, even if in the defense mechanism, the severer is a source of stimulus, the severer a resultant inflammation will be proportionally. It is admitted that in extreme cases this kind of inflammation is of such severe nature as to cause the death of a living body but these are conditions which have clearly deviated from the normal range of defense mechanism.<BR>The present paper is concerned with a discussion of the mechanism of inflammation and anti-inflammatory agents from this view point of regarding the inflammation as a definite physiological defense of the permanent functions in a living body.<BR>A major advance in the concept of anti-inflammatory agents occurred in 1949 with the discovery of cortisone and, ever since, research efforts have been quite active not only in the field of physiology but also in that of pharmacology.
- 日本大学歯学部の論文
日本大学歯学部 | 論文
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