The Role of Histamine H2 Receptor in Nasal Allergy:With special reference to its receptor binding assay

概要

論文の詳細を見る
In order to examine a possible difference in the number of H2 receptors in the inferior nasal choncha mucous between groups with and without nasal allergy, a histamine H2 receptor binding assay was attempted in human inferior nasal choncha mucous (n=46). In the receptor binding assay for the above-mentioned cell membrane specimens using 3H-tiotidine, high-and low-affinity regions were observed according to its concentration.Bmax (maximum binding volume) was 38.5±5.2 and 26.8±3.4fmol/mg protein in nasal allergic and nonallergic groups, respectively, showing a significant by higher values in the former group (P<0.05). No difference was evident in thce KD value (affinity).In patients with nasal allergy, Bmax was 41.1±5.9 in the group below 41 years of age and 29.0±19.1fmol/mg protein in the group above 40 years of age. No difference was, however, observed between the two age groups.It is well-known that the histamine H2 receptor is involved in the negative feedback mechanism that accurs during histamine release.The experimental results indicated that histamine H2 receptors changed in number in response to the occurrence of allergic rhinitis, possibly playing a role in the suppression of type I allergic rhinitis.
日本鼻科学会の論文