The Experimental Study on the Effect of Thiamine Derivative on the Kanamycin-Ototoxicity
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概要
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Electrophysiological experiments were performed in order to evaluate an effect of thiamine derivative on the kanamycin ototoxicity.Cochlecr microphonics of the rabbit was measured day-to-day with the electrode permanently implanted on the round window.One group of animals were daily given i.p. injections of kanamycin of 100mg/kg (group I). The other group got the same dose of kanamycin plus thiamine derivative (O, S-dicarbethoxythiamine) of 20mg/kg (group II).1) The curves of CM amplitude showed that there was a wide difference in the periods of onset of reduction. The curves of group II showed a more wide difference than that of group I and in a few animals of group II the periods of onset of CM reduction were far prolonged beyond that of group I.2) The clear-cut difference was observed in the slope of CM reduction between group I and group II. i.e. in the group I CM was reduced rapidly, while in the group II it was reduced with a gentle slope until the CM came to low valtage.
- 日本聴覚医学会の論文
日本聴覚医学会 | 論文
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