A fundamental examination of flomoxef sodium in the field of oral surgery.
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概要
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Flomoxef sodium (FMOX) was examined for its fundamental property in tissue concentration and antibacterial potency. The following results were obtained.<BR>1. The tissue concentrations of FMOX after one hour intravenous injection were 14.7±1.8 μg/ml, 8.5±2.1 μg/g and 4.0±3.1 μg/g in serum, gingiva and jaw, respectively.<BR>2. The rates of bacterial disappearance were judged by measuring 75 clinically isolated strains. Eighty percents of minimum inhibitory concentration (MIC<SUB>80</SUB>) on 47 strains of aerobic bacteria was 6.3 μg/ml. MIC<SUB>80</SUB> on 28 strains of anaerobic was 1.6 μg/ml.<BR>3. The tissue concentrations measured on serum and gingiva were higher than that of MIC<SUB>80</SUB> clinically isolated 75 strains. From these results, FMOX is considered to be able to prevent bacterial growth in oral infections.
- 日本歯科薬物療法学会の論文
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