Studies on bacteria and on pharmacological movement of antibiotics to sinus membrane in odontogenic maxillary sinusitis.

概要

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This study was performed to analyze the causative bacteria and pharmacological movement of antibiotics in sinus membrane in odontogenic sinusitis. A total of 257 isolates were obtained; the number of aerobes and anaerobes were 152 (69.1 %) and 105 (40.9%), respectively. Bacterial genera isolation with high frequency were Streptococcus (53 strains) and Staphylococcus (42 strains) in the aerobes, and Veillonella (50 strains) and Peptococcus (21 strains) in anaerobes. In aerobes and anaerobes, all strains except one were susceptible to CER, and more than 90% of the isolates were susceptible to CLDM. The pharmacological movement of ABPC, CER, and CLDM in sinus membrane was investigated in rats and patients with odontogenic maxillary sinusitis by measuring the concentration of the drug by the cup method. These findings suggest that ABPC, CER, CZON and CLDM would be clinically effective for the treatment of odontogenic maxillary sinusitis.
日本歯科薬物療法学会の論文