Clinical evaluation of the anti-inflammatory enzyme lysozyme (Leftose) for the treatment of ambulatory postoperative cases in oral and maxillo-facial surgery.

概要

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A clinical study was performed to examine the anti-inflammatory efficacy, safety and usefulness of Leftose®, an anti-inflammatory enzyme, on postoperative cases of oral and maxillo-facial surgery at our department from February to May, 1986. In this study, Leftose was administered to 44 ambulatory patients (27 males and 17 females) . Their age range was 10 to 77 years old. All cases were divided into two groups according to the operation method. Group A underwent hard tissue surgery, such as teeth extraction, and Group B soft tissue surgery, tumor excision or others. Patients were administered Leftose (100 mg, three times a day) after surgery for three to seven days. The results obtained are as follows. 1) According to the clinical efficacy, the ratio of "good or better" was 58.3% with Group A and 90% with Group B. In all cases, the efficacy rate was 72.8%. 2) Side effects were not observed in any cases. 3) For the general utility rating, the ratio of useful or better was 72.8%. The results of the study indicate that Leftose is a safe and useful anti-inflammatory agent for controlling postoperative inflammation in ambulatory cases of oral and maxillofacial surgery.
日本歯科薬物療法学会の論文