Blood level of the cefem antimicrobial agent, BMY-28100 in healthy volunteers.
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概要
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The blood concentrations of BMY-28100 were compared by a cross-over test in 10 healthy volunteers who were given peroral administration of 250 mg of this agent in a fasting state and after a meal.<BR>The mean blood concentration formed a peak (T<SUB>max</SUB>), demonstrating almost the same values for peak formation. C<SUB>max</SUB> for administration with fasting was approximately 1.4 times higher. The half-life (T<SUB>1/2</SUB>) was approximately 7.2 min shorter for administration with fasting. The areas under the simulation curves (AUC) for administration with fasting were 1.35 times larger than after a meal.<BR>BMY-28100 appears to be a drug which is nct susceptible to the effects of a meal.
- 日本歯科薬物療法学会の論文
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